Adenosine

Last Updated on August 19, 2026

Mechanism of Action

• Slows transmission across AV node
• It has only little effect on other myocardial cells / conduction pathways

Notes
• Adenosine receptors are found in the lungs
• Thus, adenosine can stimulate sensory nerve fibres in lungs to produce shortness of breath
• Adenosine causes bronchoconstriction

Indications

• Stable supraventricular tachycardia

Administration

Preparation

• Make sure patient has a large bore branula at antecubital fossa, with a 3-way stop cock
• 10 – 20 mL syringe with normal saline / water for injection

Administration

• Before administering IV Adenosine, warn the patient that the medication may cause transient shortness of breath / chest discomfort / nausea / flushing
• Straighten and lift up patient’s hand (the side of adenosine administration)
• Adenosine is given as rapid intravenous push, followed by 10 – 20 mL water for injection / normal saline

Dosage

Stable supraventricular tachycardia

• IV Adenosine 6 mg stat, followed by 10 – 20 mL saline flush
• If unsuccessful, to give IV Adenosine 12 mg stat 1 – 2 minutes later

Adverse Effects

• Transient unpleasant side effects: chest discomfort, nausea, flush
• Bronchoconstriction → shortness of breath
• Atrial fibrillation

Precautions

• Asthma